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  Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs

Juan, D., Perner, J., Carrillo de Santa Pau, E., Marsili, S., Ochoa, D., Chung, H. R., et al. (2016). Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs. Cell Reports, 14(5), 1246-1257. doi:10.1016/j.celrep.2016.01.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4760-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4761-F
Genre: Journal Article

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© 2016 The Authors

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 Creators:
Juan, D., Author
Perner, J., Author
Carrillo de Santa Pau, E., Author
Marsili, S., Author
Ochoa, D., Author
Chung, H. R.1, Author              
Vingron, M.2, Author              
Rico, D., Author
Valencia, A., Author
Affiliations:
1Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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 Abstract: Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs.

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Language(s): eng - English
 Dates: 2016-01-282016-02-09
 Publication Status: Published in print
 Pages: 12
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 Table of Contents: -
 Rev. Method: -
 Identifiers: PMID: 26832418
DOI: 10.1016/j.celrep.2016.01.008
ISSN: 2211-1247 (Electronic)
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Title: Cell Reports
Source Genre: Journal
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Pages: - Volume / Issue: 14 (5) Sequence Number: - Start / End Page: 1246 - 1257 Identifier: Other: 2211-1247
CoNE: /journals/resource/2211-1247