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  Altered morphology of the nucleus accumbens in persistent developmental stuttering

Neef, N., Bütfering, C., Auer, T., Metzger, F. L., Euler, H. A., Frahm, J., et al. (2018). Altered morphology of the nucleus accumbens in persistent developmental stuttering. Journal of Fluency Disorders, 55, 84-93. doi:10.1016/j.jfludis.2017.04.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-EA39-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C90E-C
Genre: Journal Article

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 Creators:
Neef, Nicole1, 2, Author              
Bütfering, Christoph1, Author
Auer, Tibor3, Author
Metzger, F. Luise1, Author
Euler, Harald A.4, Author
Frahm, J.5, Author
Paulus, Walter1, Author
Sommer, Martin1, Author
Affiliations:
1Department of Clinical Neurophysiology, University Medical Center, Göttingen, Germany, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
3MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              
4Department of Phoniatrics and Pediatric Audiology, Ruhr University, Bochum, Germany, ou_persistent22              
5Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, ou_persistent22              

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Free keywords: Goal-directed behavior; Social-motivational behavior; Nucleus accumbens; Vertex-wise shape analysis
 Abstract: Purpose: Neuroimaging studies in persistent developmental stuttering repeatedly report altered basal ganglia functions. Together with thalamus and cerebellum, these structures mediate sensorimotor functions and thus represent a plausible link b etween stuttering and neuroanatomy. However, stuttering is a complex, multifactorial disorder. Besides sensorimotor functions, emotional and social -motivational factors constitute major aspects of the disorder. Here, we investigated cortical and subcortica l grey matter regions to study whether persistent developmental stuttering is also linked to alterations of limbic structures. Methods: The study included 33 right-handed participants who stutter and 34 right-handed control participants matched for sex, age, and education. Structural images were acquired using magnetic resonance imaging to estimate volumetric characteristics of the nucleus accumbens, hippocampus, amygdala, pallidum, putamen, caudate nucleus, and thalamus. Results: Volumetric comparisons and vertex -based shape comparisons revealed structural differences. The right nucleus accumbens was larger in participants who stutter compared to controls. Conclusion: Recent theories of basal ganglia functions suggest that the nucleus accumbens is a motivation-to-movement interface. A speaker intends to reach communicative goals, but stuttering can derail these efforts. It is therefore highly plausible to find alterations in the motivation-to -movement interface in stuttering. While behavioral studies of stuttering sought to find links between the limbic and sensorimotor system, we provide the first neuroimaging evidence of alterations in the limbic system. Thus, our findings might initialize a unified neurobiological framework of persistent developmental stuttering that integrates sensorimotor and social -motivational neuroanatomical circuitries.

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Language(s): eng - English
 Dates: 2016-07-112017-04-042017-05-242018-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jfludis.2017.04.002
PMID: 28595893
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : NE 1841/1-1 ; SO 429/4-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01GQ0812
Funding program : -
Funding organization : German Federal Ministry for Education and Research (BMBF)
Project name : -
Grant ID : MC-A060-53114
Funding program : -
Funding organization : Medical Research Council (MRC)

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Title: Journal of Fluency Disorders
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 55 Sequence Number: - Start / End Page: 84 - 93 Identifier: ISSN: 0094-730X
CoNE: /journals/resource/0094-730X