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  Sustained effects of acupuncture stimulation investigated with centrality mapping analysis

Long, X., Huang, W., Napadow, V., Liang, F., Pleger, B., Villringer, A., et al. (2016). Sustained effects of acupuncture stimulation investigated with centrality mapping analysis. Frontiers in Human Neuroscience, 10: 510. doi:10.3389/fnhum.2016.00510.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-EB36-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1E53-F
Genre: Journal Article

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 Creators:
Long, Xiangyu1, Author              
Huang, Wenjing2, 3, Author
Napadow, Vitaly4, 5, Author
Liang, Fanrong3, Author
Pleger, Burkhard1, Author              
Villringer, Arno1, 6, Author              
Witt, Claudia M.2, 7, Author
Nierhaus, Till1, 6, 8, Author              
Pach, Daniel2, Author
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medicine Berlin, Germany, ou_persistent22              
3Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, China, ou_persistent22              
4Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
5Department of Radiology, Logan College of Chiropractic, Chesterfield, MO, USA, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Institute for Complementary and Integrative Medicine, University Hospital Zurich, Switzerland, ou_persistent22              
8Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              

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Free keywords: Resting-state fMRI; Acupuncture; Functional connectivity; Centrality; Pain
 Abstract: Acupuncture can have instant and sustained effects, however, its mechanisms of action are still unclear. Here, we investigated the sustained effect of acupuncture by evaluating centrality changes in resting-state functional magnetic resonance imaging after manually stimulating the acupuncture point ST36 at the lower leg or two control point locations (CP1 same dermatome, CP2 different dermatome). Data from a previously published experiment evaluating instant BOLD effects and S2-seed-based resting state connectivity was re-analyzed using eigenvector centrality mapping and degree centrality mapping. These data-driven methods might add new insights into sustained acupuncture effects on both global and local inter-region connectivity (centrality) by evaluating the summary of connections of every voxel. We found higher centrality in parahippocampal gyrus and middle temporal gyrus after ST36 stimulation in comparison to the two control points. These regions are positively correlated to major hubs of the default mode network, which might be the primary network affected by chronic pain. The stronger integration of both regions within the whole-brain connectome after stimulation of ST36 might be a potential contributor to pain modulation by acupuncture. These findings highlight centrality mapping as a valuable analysis for future imaging studies investigating clinically relevant outcomes associated with physiological response to acupuncture stimulation.

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Language(s): eng - English
 Dates: 2016-06-022016-09-272016-10-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2016.00510
PMID: 27803655
PMC: PMC5067410
Other: eCollection 2016
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 510 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: /journals/resource/1662-5161