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  The role of titanium surface nanostructuring on preosteoblast morphology, adhesion, and migration

Zhukova, Y., Hiepen, C., Knaus, P., Osterland, M., Prohaska, S., Dunlop, J. W. C., et al. (2017). The role of titanium surface nanostructuring on preosteoblast morphology, adhesion, and migration. Advanced Healthcare Materials, 6(15): 1601244. doi:10.1002/adhm.201601244.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-F55C-8 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000B-72EE-9
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 Urheber:
Zhukova, Yulia1, Autor           
Hiepen, Christian, Autor
Knaus, Petra, Autor
Osterland, Marc, Autor
Prohaska, Steffen, Autor
Dunlop, John W. C.2, Autor                 
Fratzl, Peter3, Autor           
Skorb, Ekaterina V.1, Autor           
Affiliations:
1Katja Skorb (Indep. Res.), Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2231640              
2John Dunlop, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863291              
3Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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 Zusammenfassung: Surface structuring of titanium-based implants is known to modulate the behavior of adherent cells, but the influence of different nanotopographies is poorly understood. The aim is to investigate preosteoblast proliferation, adhesion, morphology, and migration on surfaces with similar surface chemistry but distinct nanotopographical features. Sonochemical treatment and anodic oxidation are employed to fabricate disordered, mesoporous titania (TMS) and ordered titania nanotubular (TNT) topographies on titanium, respectively. Morphological evaluation reveals that cells are polygonal and well-spread on TMS, but display an elongated, fibroblast-like morphology on TNT surfaces, while they are much flatter on glass. Both nanostructured surfaces impair cell adhesion, but TMS is more favorable for cell growth due to its support of cell attachment and spreading in contrast to TNT. A quantitative wound healing assay in combination with live-cell imaging reveals that cell migration on TMS surfaces has a more collective character than on other surfaces, probably due to a closer proximity between neighboring migrating cells on TMS. The results indicate distinctly different cell adhesion and migration on ordered and disordered titania nanotopographies, providing important information that can be used in optimizing titanium-based scaffold design to foster bone tissue growth and repair while allowing for the encapsulation of drugs into porous titania layer.

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 Datum: 2017-03-302017
 Publikationsstatus: Erschienen
 Seiten: 13
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/adhm.201601244
DOI: 10.1002/adhm.201770077
PMID: 0530
 Art des Abschluß: -

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Titel: Advanced Healthcare Materials
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Weinheim : Wiley-VCH
Seiten: - Band / Heft: 6 (15) Artikelnummer: 1601244 Start- / Endseite: - Identifikator: ISSN: 2192-2640