Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Brain networks modulated by subthalamic nucleus deep brain stimulation

Accolla, E. A., Ruiz, M. H., Horn, A., Schneider, G.-H., Schmitz-Hübsch, T., Draganski, B., et al. (2016). Brain networks modulated by subthalamic nucleus deep brain stimulation. Brain, 139(9), 2503-2515. doi:10.1093/brain/aww182.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Accolla_Ruiz_2016.pdf (Verlagsversion), 977KB
Name:
Accolla_Ruiz_2016.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Accolla, Ettore A.1, 2, Autor
Ruiz, Maria Herrojo1, 3, Autor
Horn, Andreas1, Autor
Schneider, Gerd-Helge4, Autor
Schmitz-Hübsch, Tanja1, Autor
Draganski, Bogdan5, 6, Autor           
Kühn, Andrea A.1, 7, 8, 9, Autor
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Deaprtment of Neurology, University of Fribourg, Switzerland, ou_persistent22              
3Department of Psychology, Goldsmiths, University of London, United Kingdom, ou_persistent22              
4Department of Neurosurgery, Charité University Medicine Berlin, Germany, ou_persistent22              
5Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
8NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
9German Center for Neurodegenerative Diseases, Berlin, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Deep brain stimulation; Parkinson’s disease; Parkinson’s disease: imaging; Subthalamic nucleus; Beta oscillations
 Zusammenfassung: Deep brain stimulation of the subthalamic nucleus is an established treatment for the motor symptoms of Parkinson’s disease.
Given the frequent occurrence of stimulation-induced affective and cognitive adverse effects, a better understanding about the role
of the subthalamic nucleus in non-motor functions is needed. The main goal of this study is to characterize anatomical circuits
modulated by subthalamic deep brain stimulation, and infer about the inner organization of the nucleus in terms of motor and
non-motor areas. Given its small size and anatomical intersubject variability, functional organization of the subthalamic nucleus is
difficult to investigate
in vivo
with current methods. Here, we used local field potential recordings obtained from 10 patients with
Parkinson’s disease to identify a subthalamic area with an analogous electrophysiological signature, namely a predominant beta
oscillatory activity. The spatial accuracy was improved by identifying a single contact per macroelectrode for its vicinity to the
electrophysiological source of the beta oscillation. We then conducted whole brain probabilistic tractography seeding from the
previously identified contacts, and further described connectivity modifications along the macroelectrode’s main axis. The desig-
nated subthalamic ‘beta’ area projected predominantly to motor and premotor cortical regions additional to connections to limbic
and associative areas. More ventral subthalamic areas showed predominant connectivity to medial temporal regions including
amygdala and hippocampus. We interpret our findings as evidence for the convergence of different functional circuits within
subthalamic nucleus’ portions deemed to be appropriate as deep brain stimulation target to treat motor symptoms in Parkinson’s
disease. Potential clinical implications of our study are illustrated by an index case where deep brain stimulation of estimated
predominant non-motor subthalamic nucleus induced hypomanic behaviour.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2016-05-312016-04-202016-06-152016-07-132016-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/brain/aww182
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Brain
  Andere : Brain
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Macmillan
Seiten: - Band / Heft: 139 (9) Artikelnummer: - Start- / Endseite: 2503 - 2515 Identifikator: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135