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  Subregional mesiotemporal network topology is altered in temporal lobe epilepsy

Bernhardt, B. C., Bernasconi, N., Hong, S.-J., Dery, S., & Bernasconi, A. (2016). Subregional mesiotemporal network topology is altered in temporal lobe epilepsy. Cerebral Cortex, 26(7), 3237-3248. doi:10.1093/cercor/bhv166.

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資料種別: 学術論文

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説明:
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OA-Status:
Green

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 作成者:
Bernhardt, Boris C.1, 2, 著者           
Bernasconi, Neda1, 著者
Hong, Seok-Jun1, 著者
Dery, Sebastian1, 著者
Bernasconi, Andrea1, 著者
所属:
1Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
2Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              

内容説明

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キーワード: Connectivity; Eepilepsy; Graph theory; MRI; Temporal lobe
 要旨: Temporal lobe epilepsy (TLE) is the most frequent drug-resistant epilepsy in adults and commonly associated with variable
degrees of mesiotemporal atrophy on magnetic resonance imaging (MRI). Analyses of inter-regional connectivity have unveiled
disruptions in large-scale cortico-cortical networks; little is known about the topological organization of the mesiotemporal
lobe, the limbic subnetwork central to the disorder. We generated covariance networks based on high-resolution MRI surface-
shape descriptors of the hippocampus, entorhinal cortex, and amygdala in 134 TLE patients and 45 age- and sex-matched
controls. Graph-theoretical analysis revealed increased path length and clustering in patients, suggesting a shift toward a more
regularized arrangement;
fi
ndings were reproducible after split-half assessment and across 2 parcellation schemes. Analysis of
inter-regional correlations and module participation showed increased within-structure covariance, but decreases between
structures, particularly with regards to the hippocampus and amygdala. While higher clustering possibly re
fl
ects topological
consequences of axonal sprouting, decreases in interstructure covariance may be aconsequence of disconnection within limbic
circuitry. Preoperative network parameters, specifically the segregation of the ipsilateral hippocampus, predicted long-term
seizure freedom after surgery.

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言語: eng - English
 日付: 2015-07-282016-07
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1093/cercor/bhv166
PMID: 26223262
PMC: PMC4898674
その他: Epub 2015
 学位: -

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Project information

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Project name : -
Grant ID : MOP-123520, MOP-57840
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : -
Funding program : Jeanne Timmins Costello Fellowship
Funding organization : Montreal Neurological Institute and Hospital

出版物 1

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出版物名: Cerebral Cortex
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: New York, NY : Oxford University Press
ページ: - 巻号: 26 (7) 通巻号: - 開始・終了ページ: 3237 - 3248 識別子(ISBN, ISSN, DOIなど): ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440