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  Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression

Kim, E. S., Ackermann, C., Toth, I., Dierks, P., Eberhard, J. M., Wroblewski, R., et al. (2017). Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression. Journal of Leukocyte Biology, 101(5), 1263-1271. doi:10.1189/jlb.5A0816-346R.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-F6F4-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-839A-6
Genre: Journal Article

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Kim, E. S., Author
Ackermann, C., Author
Toth, I., Author
Dierks, P., Author
Eberhard, J. M., Author
Wroblewski, R., Author
Scherg, F., Author
Geyer, Matthias1, Author
Schmidt, R. E., Author
Beisel, C., Author
Bockhorn, M., Author
Haag, F., Author
Lunzen, J., Author
Schulze zur Wiesch, J., Author
Affiliations:
1Research Group Physical Biochemistry, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173686              

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 Abstract: Recently, alterations of the T cell expression of the ectonucleotidases, CD39 and CD73, during HIV infection have been described. Here, peripheral (n = 70) and lymph nodal B cells (n = 10) of patients with HIV at different stages of disease as well as uninfected individuals were analyzed via multicolor flow cytometry with regard to expression of CD39 and CD73 and differentiation, proliferation, and exhaustion status. Patients with chronic, untreated HIV showed a significantly decreased frequency of CD73‐expressing B cells (P < 0.001) compared with healthy controls. Decreased frequencies of CD39+CD73+ B cells in patients with HIV correlated with low CD4+ counts (P < 0.0256) as well as increased proliferation and exhaustion status as determined by Ki‐67 and programmed death‐1 expression. Down‐regulation of CD73 was observed in naive and memory B cells as determined by CD27 and CD21. Neither HIV elite controller patients nor antiretroviral therapy–treated patients had significantly lower CD39 and CD73 expression on B cells compared with healthy controls. Of importance, low CD73+ expression on B cells was associated with modulated in vitro B cell function. Further in vivo studies are warranted to evaluate the in vivo role of phenotypic loss of CD73 in B cell dysregulation in HIV.

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Language(s): eng - English
 Dates: 2017-02-132017-05
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1189/jlb.5A0816-346R
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Title: Journal of Leukocyte Biology
  Other : J Leukoc Biol
Source Genre: Journal
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Publ. Info: New York : Liss
Pages: - Volume / Issue: 101 (5) Sequence Number: - Start / End Page: 1263 - 1271 Identifier: ISSN: 0741-5400
CoNE: https://pure.mpg.de/cone/journals/resource/954925539169