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  Immune function in Amazonian horticulturalists

Blackwell, A. D., Trumble, B. C., Suarez, I. M., Stieglitz, J., Beheim, B., Snodgrass, J. J., et al. (2016). Immune function in Amazonian horticulturalists. Annals of Human Biology, 43(4), 382-396. doi:10.1080/03014460.2016.1189963.

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 Creators:
Blackwell, Aaron D.1, Author                 
Trumble, Benjamin C., Author
Suarez, Ivan Maldonado, Author
Stieglitz, Jonathan, Author
Beheim, Bret1, Author                 
Snodgrass, J. Josh, Author
Kaplan, Hillard, Author
Gurven, Michael, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: horticulturalists, Immune function, life history, South America, Tsimane
 Abstract: Background: Amazonian populations are exposed to diverse parasites and pathogens, including protozoal, bacterial, fungal and helminthic infections. Yet much knowledge of the immune system is based on industrialised populations where these infections are relatively rare.Aim: This study examines distributions and age-related differences in 22 measures of immune function for Bolivian forager-horticulturalists and US and European populations.Subjects and methods: Subjects were 6338 Tsimane aged 0–90 years. Blood samples collected between 2004–2014 were analysed for 5-part blood differentials, C-reactive protein, erythrocyte sedimentation rate (ESR) and total immunoglobulins E, G, A and M. Flow cytometry was used to quantify naïve and non-naïve CD4 and CD8 T cells, natural killer cells, and B cells.Results: Compared to reference populations, Tsimane have elevated levels of most immunological parameters, particularly immunoglobulins, eosinophils, ESR, B cells, and natural killer cells. However, monocytes and basophils are reduced and naïve CD4 cells depleted in older age groups.Conclusion: Tsimane ecology leads to lymphocyte repertoires and immunoglobulin profiles that differ from those observed in industrialised populations. These differences have consequences for disease susceptibility and co-vary with patterns of other life history traits, such as growth and reproduction.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/03014460.2016.1189963
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Title: Annals of Human Biology
Source Genre: Journal
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Pages: - Volume / Issue: 43 (4) Sequence Number: - Start / End Page: 382 - 396 Identifier: ISBN: 0301-4460