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  Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells

Iwanami, N., Hess, I., Schorpp, M., & Boehm, T. (2017). Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells. Methods in Cell Biology, 138, 151-161. doi:10.1016/bs.mcb.2016.08.003.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-8570-B Version Permalink: https://hdl.handle.net/21.11116/0000-0009-211F-0
Genre: Journal Article

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https://www.sciencedirect.com/science/article/pii/S0091679X1630139X?via%3Dihub (Publisher version)
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 Creators:
Iwanami, Norimasa1, Author
Hess, Isabel1, Author
Schorpp, Michael1, Author
Boehm, Thomas1, Author           
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: Traditionally, transplantation has been a major experimental procedure to study the development and function of hematopoietic and immune systems. Here, we describe the use of a zebrafish strain lacking definitive hematopoiesis (cmybI181N) for interspecific analysis of hematopoietic and immune cell development. Without conditioning prior to transplantation, allogeneic and xenogeneic hematopoietic progenitor cells stably engraft in adult zebrafish homozygous for the cmyb mutation. This unique animal model can be used to genetically and functionally disentangle universal and species-specific contributions of the microenvironment to hematopoietic progenitor cell maintenance and development

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/bs.mcb.2016.08.003
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Title: Methods in Cell Biology
  Other : Methods Cell Biol.
Source Genre: Journal
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Publ. Info: San Diego [etc.] : Academic Press
Pages: - Volume / Issue: 138 Sequence Number: - Start / End Page: 151 - 161 Identifier: ISSN: 0091-679X
CoNE: https://pure.mpg.de/cone/journals/resource/991042724273554