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  Conserved RNA polymerase II initiation complex structure.

Hantsche, M., & Cramer, P. (2017). Conserved RNA polymerase II initiation complex structure. Current Opinion in Structural Biology, 47, 17-22. doi:10.1016/j.sbi.2017.03.013.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-1D96-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2E5B-7
Genre: Journal Article

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 Creators:
Hantsche, M.1, Author              
Cramer, P.1, Author              
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1Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1863498              

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 Abstract: Recent cryo-electron microscopic studies have arrived at atomic models of the core transcription initiation complex comprising RNA polymerase (Pol) II and the basal transcription factors TBP, TFIIA, TFIIB, TFIIE, and TFIIF. A detailed comparison of two independently derived yeast and human core initiation complex structures reveals that they are virtually identical, demonstrating the conservation of the basic transcription machinery amongst eukaryotes. The additional factors TFIID, TFIIH, and Mediator have been located on the periphery of the core initiation complex, providing the topology of the entire initiation assembly, which comprises approximately 70 polypeptides with a molecular weight of ∼4 Megadalton.

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Language(s): eng - English
 Dates: 2017-04-222017-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.sbi.2017.03.013
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Title: Current Opinion in Structural Biology
Source Genre: Journal
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Pages: - Volume / Issue: 47 Sequence Number: - Start / End Page: 17 - 22 Identifier: -