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  Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?

Huber, E., Lachapelle, P., Sutter, R., Curt, A., & Freund, P. (2017). Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury? Annals of Neurology, 81(5), 740-748. doi:10.1002/ana.24932.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-25F1-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-4D38-7
Genre: Journal Article

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 Creators:
Huber, Eveline1, Author
Lachapelle, Patrice1, Author
Sutter, Reto2, Author
Curt, Armin1, Author
Freund, Patrick1, 3, 4, 5, Author           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Radiology, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
4Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Midsagittal tissue bridges; Recovery; Spinal cord injury
 Abstract: T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At one month post-injury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at one month post-injury were associated with neurological and functional recovery at 1 year follow-up. Neuroimaging biomarkers of lesion area and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials.

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Language(s): eng - English
 Dates: 2016-09-282017-04-042017-04-102017-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/ana.24932
PMID: 28393423
 Degree: -

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Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : Clinical Research Priority Program (CRPP)
Funding organization : University Zurich
Project name : -
Grant ID : WFL‐CH‐007/14
Funding program : -
Funding organization : Wings for Life, Austria

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Title: Annals of Neurology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Boston : American Neurological Association
Pages: - Volume / Issue: 81 (5) Sequence Number: - Start / End Page: 740 - 748 Identifier: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748