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  Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia.

Mohr, S., Doebele, C., Comoglio, F., Berg, T., Beck, J., Bohnenberger, H., et al. (2017). Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia. Cancer Cell, 31(4), 549-562. doi:10.1016/j.ccell.2017.03.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-288D-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-57E5-B
Genre: Journal Article

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 Creators:
Mohr, S., Author
Doebele, C., Author
Comoglio, F., Author
Berg, T., Author
Beck, J., Author
Bohnenberger, H., Author
Alexe, G., Author
Corso, J.1, Author              
Ströbel, P., Author
Wachter, A., Author
Beissbarth, T., Author
Schnutgen, F., Author
Cremer, A., Author
Haetscher, N., Author
Göllner, S., Author
Rouhi, A., Author
Palmqvist, L., Author
Rieger, M. A., Author
Schroeder, T., Author
Bönig, H., Author
Müller-Tidow, C., AuthorKuchenbauer, F., AuthorSchütz, E., AuthorGreen, A. R., AuthorUrlaub, H.1, Author              Stegmaier, K., AuthorHumphries, R. K., AuthorServe, H., AuthorOellerich, T., Author more..
Affiliations:
1Research Group of Bioanalytical Mass Spectrometry, MPI for Biophysical Chemistry, Max Planck Society, ou_578613              

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 Abstract: The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis revealed that Meis1 increased Syk protein expression and activity. Syk upregulation occurs through a Meis1-dependent feedback loop. By dissecting this loop, we show that Syk is a direct target of miR-146a, whose expression is indirectly regulated by Meis1 through the transcription factor PU.1. In the context of Hoxa9 overexpression, Syk signaling induces Meis1, recapitulating several leukemogenic features of Hoxa9/Meis1-driven leukemia. Finally, Syk inhibition disrupts the identified regulatory loop, prolonging survival of mice with Hoxa9/Meis1-driven leukemia.

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Language(s): eng - English
 Dates: 2017-04-102017-04-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.ccell.2017.03.001
 Degree: -

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Title: Cancer Cell
Source Genre: Journal
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Pages: - Volume / Issue: 31 (4) Sequence Number: - Start / End Page: 549 - 562 Identifier: -