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  Salt dependence of DNA structural stabilities in solution. Theoretical predictions versus experiments.

Soumpasis, D. (1988). Salt dependence of DNA structural stabilities in solution. Theoretical predictions versus experiments. Journal of Biomolecular Structure and Dynamics, 6(3), 563-574. doi:10.1080/07391102.1988.10506507.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2E48-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2E4C-B
Genre: Journal Article

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Soumpasis, D.M.1, Author              
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1Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society, ou_578628              

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 Abstract: The predictions of currently available theories for treating DNA-diffuse ionic cloud free energy contributions to conformational stability have been tested against experimental data for salt induced B-Z and B-A transitions. The theories considered are (i) Manning's counterion condensation approach (CC), (ii) the idealized Poisson-Boltzmann approximation (PB), and (iii) the potentials of mean force (PMF) approach proposed by Soumpasis. As far as we can judge from comparison with the set of experimental data currently available, it is found that only the latter theory yields satisfactory quantitative results for the dependence of the B-Z and B-A relative stabilities on monovalent salt concentration. The correct application of the PB and CC theories does not yield very low salt Z-B transitions, in contradiction to earlier assertions. At low salt concentrations the PB theory is qualitatively correct in predicting that the B form is electrostatically more favorable than both the A and B forms, whereas the CC theory is qualitatively wrong predicting that Z-DNA is more stable than both B and A DNA.

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Language(s): eng - English
 Dates: 1988-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1080/07391102.1988.10506507
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Title: Journal of Biomolecular Structure and Dynamics
Source Genre: Journal
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Pages: - Volume / Issue: 6 (3) Sequence Number: - Start / End Page: 563 - 574 Identifier: -