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  undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1.

Balling, R., Deutsch, U., & Gruss, P. (1988). undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell, 55(3), 531-535. doi:10.1016/0092-8674(88)90039-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2F40-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-2F42-8
Genre: Journal Article

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 Creators:
Balling, R.1, Author              
Deutsch, U.1, Author              
Gruss, P.1, Author              
Affiliations:
1Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

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 Abstract: undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in intervertebral disks along the entire vertebral column. We localized the Pax 1 gene on chromosome 2 between β2-microglobulin and the agouti locus to an area where un maps. DNA analysis of the un mutant revealed a point mutation in a highly conserved part of the paired box of Pax 1, leading to a Gly-Ser replacement. The chromosomal location and the mutation in the paired box of un mice in conjunction with Pax 1 gene expression in wild-type mice implicate a causative role of Pax 1 in generation of the vertebral column.

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Language(s): eng - English
 Dates: 1988-11-04
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/0092-8674(88)90039-6
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 55 (3) Sequence Number: - Start / End Page: 531 - 535 Identifier: -