English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study

Kumsta, R., Stevens, S., Brookes, K., Schlotz, W., Castle, J., Beckett, C., et al. (2010). 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study. Journal of Child Psychology and Psychiatry, 51(7), 755-762. doi:10.1111/j.1469-7610.2010.02249.x.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-301D-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-301E-2
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kumsta, R., Author
Stevens, S., Author
Brookes, K., Author
Schlotz, W.1, Author              
Castle, J., Author
Beckett, C., Author
Kreppner, J., Author
Rutter, M., Author
Sonuga-Barke, E., Author
Affiliations:
1University of Southampton, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene x environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence.

Details

show
hide
Language(s):
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 20345836
ISSN: 1469-7610 (Electronic)0021-9630 (Linking)
DOI: 10.1111/j.1469-7610.2010.02249.x
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Child Psychology and Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 51 (7) Sequence Number: - Start / End Page: 755 - 762 Identifier: -