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  Proton electrochemical gradient: Driving and regulating neurotransmitter uptake.

Farsi, Z., Jahn, R., & Woehler, A. (2017). Proton electrochemical gradient: Driving and regulating neurotransmitter uptake. Bioessays, 39(5): 1600240. doi:10.1002/bies.201600240.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-309D-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2092-5
Genre: Journal Article

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2431964.pdf (Publisher version), 727KB
 
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 Creators:
Farsi, Z., Author
Jahn, R.1, Author              
Woehler, A., Author
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1Department of Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578595              

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Free keywords: buffering capacity; ion-proton exchangers; neurotransmitter uptake; proton electrochemical gradient; proton pump; vesicular transporters
 Abstract: Accumulation of neurotransmitters in the lumen of synaptic vesicles (SVs) relies on the activity of the vacuolar-type H+-ATPase. This pump drives protons into the lumen, generating a proton electrochemical gradient (ΔμH+) across the membrane. Recent work has demonstrated that the balance between the chemical (ΔpH) and electrical (ΔΨ) components of ΔμH+ is regulated differently by some distinct vesicle types. As different neurotransmitter transporters use ΔpH and ΔΨ with different relative efficiencies, regulation of this gradient balance has the potential to influence neurotransmitter uptake. Nevertheless, the underlying mechanisms responsible for this regulation remain poorly understood. In this review, we provide an overview of current neurotransmitter uptake models, with a particular emphasis on the distinct roles of the electrical and chemical gradients and current hypotheses for regulatory mechanisms.

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Language(s): eng - English
 Dates: 2017-04-062017-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/bies.201600240
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Title: Bioessays
Source Genre: Journal
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Pages: 9 Volume / Issue: 39 (5) Sequence Number: 1600240 Start / End Page: - Identifier: -