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  Mechanisms of vortices termination in the cardiac muscle

Hornung, D., Biktashev, V. N., Otani, N. F., Shajahan, T. K., Baig, T., Berg, S., et al. (2017). Mechanisms of vortices termination in the cardiac muscle. Royal Society Open Sience, 4(3): 170024. doi:10.1098/rsos.170024.

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 Creators:
Hornung, Daniel1, Author              
Biktashev, V. N., Author
Otani, N. F., Author
Shajahan, T. K., Author
Baig, Tariq1, Author              
Berg, Sebastian1, Author              
Han, S., Author
Krinski, Valentin I.1, Author              
Luther, Stefan1, Author              
Affiliations:
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063288              

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Free keywords: nonlinear waves, weakly pinned vortices, cardiac fibrillation, implantable defibrillator
 Abstract: We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation.

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Language(s): eng - English
 Dates: 2017-03-15
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1098/rsos.170024
 Degree: -

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Title: Royal Society Open Sience
Source Genre: Journal
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Pages: 9 Volume / Issue: 4 (3) Sequence Number: 170024 Start / End Page: - Identifier: -