Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Ramot, Assaf; Jiang, Zhiying; Tian, Jin-Bin; Nahum, Tali; Kuperman, Yael; Justice, Nicholas; Chen, Alon

doi:10.1038/nn.4491

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Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Ramot, A., Jiang, Z., Tian, J.-B., Nahum, T., Kuperman, Y., Justice, N., et al. (2017). Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. NATURE NEUROSCIENCE, 20(3), 385-388. doi:10.1038/nn.4491.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-A7BB-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-A7BC-2

Genre: Journal Article

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Creators:
Ramot, Assaf^{1, 2}, Author
Jiang, Zhiying¹, Author
Tian, Jin-Bin¹, Author
Nahum, Tali^{1, 2}, Author
Kuperman, Yael¹, Author
Justice, Nicholas¹, Author
Chen, Alon^{1, 2}, Author

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1external, ou_persistent22
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294

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Abstract: The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

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Language(s): eng - English

Dates: Date issued: 2017-03

Publication Status: Issued

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Identifiers: ISI: 000394920400014
DOI: 10.1038/nn.4491

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Title: NATURE NEUROSCIENCE

Source Genre: Journal

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Pages: - Volume / Issue: 20 (3) Sequence Number: - Start / End Page: 385 - 388 Identifier: ISSN: 1097-6256