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  Alcohol reduces prefrontal cortical excitability in humans: A combined TMS and EEG study

Kähkönen, S., Wilenius, J., Nikulin, V. V., Ollikainen, M., & Ilmoniemi, R. J. (2003). Alcohol reduces prefrontal cortical excitability in humans: A combined TMS and EEG study. Neuropsychopharmacology, 28, 747-754. doi:10.1038/sj.npp.1300099.

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 Creators:
Kähkönen, Seppo, Author
Wilenius, Juha, Author
Nikulin, Vadim V.1, Author           
Ollikainen, Marko, Author
Ilmoniemi, Risto J., Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Alcohol; Electroencephalography; Prefrontal cortex; Transcranial magnetic stimulation
 Abstract: The effects of alcohol (0.8 g/kg) on the prefrontal cortex were studied in nine healthy subjects using the technique of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG). A total of 120 magnetic pulses were delivered with a figure-of-eight coil to the left prefrontal cortex at the rate of 0.4–0.7 Hz. The EEG was recorded simultaneously with 60 scalp electrodes (41 electrodes were used for analysis); the TMS-evoked activation was estimated by the area under the global mean field amplitude (GMFA) time curve. TMS caused changes in EEG activity lasting up to 270 ms poststimulus. Alcohol decreased GMFA at 30–270 ms poststimulus (713plusminus303 vs 478plusminus142 muV ms; p=0.007). Alcohol-induced differences were most pronounced at anterior electrodes. These results suggest that alcohol reduces the excitability in the prefrontal cortex.

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Language(s): eng - English
 Dates: 2002-10-112002-04-262002-10-182003
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/sj.npp.1300099
 Degree: -

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Title: Neuropsychopharmacology
Source Genre: Journal
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Publ. Info: New York, NY : No longer published by Elsevier
Pages: - Volume / Issue: 28 Sequence Number: - Start / End Page: 747 - 754 Identifier: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485