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  Acute tryptophan depletion does not change somatosensory evoked magnetic fields

Kähkönen, S., Ahveninen, J., Jääskeläinen, I. P., Pennanen, S., Liesivuori, J., & Nikulin, V. V. (2003). Acute tryptophan depletion does not change somatosensory evoked magnetic fields. Psychopharmacology, 170(3), 332-333. doi:10.1007/s00213-003-1560-5.

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Kähkönen, Seppo, Author
Ahveninen, Jyrki, Author
Jääskeläinen, Iiro P., Author
Pennanen, Sirpa, Author
Liesivuori, Jyrki, Author
Nikulin, Vadim V.1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Magnetoencephalography; Serotonin; Somatosensory evoked magnetic fields; Tryptophan
 Abstract: Rationale Serotonin is shown to regulate the activity of primary auditory cortex, but little is known about serotonin modulation of other sensory cortices. Methods We investigated somatosensory evoked magnetic fields (SEF) to left median nerve stimulation in eight healthy subjects in a double-blind, controlled, cross-over design study after acute tryptophan depletion (ATD) and control mixture. SEFs were recorded with the whole-head magnetoencephalography 6 h after ingestion of mixtures. The SEF sources and strength were estimated by a least-squares fit of a single equivalent current dipole. Results ATD decreased the total and free TPR levels by 75 and 48% and control mixture increased them by 98% and 44%. ATD had no effect on the amplitudes or latencies of SEF components. The source locations of the responses were not significantly affected by ATD. Conclusion Serotonin does not affect stimuli processing in the primary somatosensory cortex.

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Language(s): eng - English
 Dates: 2003-07-042003-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00213-003-1560-5
 Degree: -

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Title: Psychopharmacology
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 170 (3) Sequence Number: - Start / End Page: 332 - 333 Identifier: ISSN: 0033-3158
CoNE: https://pure.mpg.de/cone/journals/resource/954925436478