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  Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance

Gong, J., Körner, R., Gaitanos, L., & Klein, R. (2016). Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. The Journal of Cell Biology, 214(1), 35-44. doi:10.1083/jcb.201601085.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-41E8-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-41E9-4
Genre: Journal Article

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 Creators:
Gong, Jingyi1, Author              
Körner, Roman2, Author              
Gaitanos, Louise1, Author              
Klein, Rüdiger1, Author              
Affiliations:
1Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society, ou_1113546              
2Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

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Free keywords: EXTRACELLULAR VESICLES; NERVOUS-SYSTEM; REPULSION; ENDOCYTOSIS; RECEPTORS; SECRETION; POPULATIONS; BIOGENESIS; PROTEOMICS; PROTEINSCell Biology;
 Abstract: The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes represents a novel mode of intercellular communication. Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands have very important roles in such biologically diverse processes as neuronal development, plasticity, and pathological diseases. Until now, it was thought that ephrin-Eph signaling requires direct cell contact. Although the biological functions of ephrin-Eph signaling are well understood, our mechanistic understanding remains modest. Here we report the release of EVs containing Ephs and ephrins by different cell types, a process requiring endosomal sorting complex required for transport (ESCRT) activity and regulated by neuronal activity. Treatment of cells with purified EphB2(+) EVs induces ephrinB1 reverse signaling and causes neuronal axon repulsion. These results indicate a novel mechanism of ephrin-Eph signaling independent of direct cell contact and proteolytic cleavage and suggest the participation of EphB2(+) EVs in neural development and synapse physiology.

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Language(s): eng - English
 Dates: 2016-01-252016-06-072016-06-272016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000379283500007
DOI: 10.1083/jcb.201601085
 Degree: -

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Project name : This study was funded by the Max Planck Society and the Deutsche Forschungsgemeinschaft (SyNergy).
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Funding program : -
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Title: The Journal of Cell Biology
  Other : JBC
Source Genre: Journal
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Publ. Info: New York, NY : Rockefeller Institute Press
Pages: - Volume / Issue: 214 (1) Sequence Number: - Start / End Page: 35 - 44 Identifier: ISSN: 0021-9525
CoNE: https://pure.mpg.de/cone/journals/resource/991042742946024_2