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  Mechanisms of long noncoding RNA function in development and disease

Schmitz, S. U., Grote, P., & Herrmann, B. G. (2016). Mechanisms of long noncoding RNA function in development and disease. Cellular and Molecular Life Sciences, 73(13), 2491-2509. doi:10.1007/s00018-016-2174-5.

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© The Author(s) 2016. This article is published with open access at Springerlink.com
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 Creators:
Schmitz, Sandra U.1, Author           
Grote, Philipp, Author
Herrmann, Bernhard G.1, Author           
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1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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Free keywords: LncRNA - Differentiation - Cardiovascular disease - Cancer - Gene regulation - Chromatin - Epigenetics - Genome organization
 Abstract: Since decades it has been known that non-protein-coding RNAs have important cellular functions. Deep sequencing recently facilitated the discovery of thousands of novel transcripts, now classified as long noncoding RNAs (lncRNAs), in many vertebrate and invertebrate species. LncRNAs are involved in a wide range of cellular mechanisms, from almost all aspects of gene expression to protein translation and stability. Recent findings implicate lncRNAs as key players of cellular differentiation, cell lineage choice, organogenesis and tissue homeostasis. Moreover, lncRNAs are involved in pathological conditions such as cancer and cardiovascular disease, and therefore provide novel biomarkers and pharmaceutical targets. Here we discuss examples illustrating the versatility of lncRNAs in gene control, development and differentiation, as well as in human disease.

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Language(s): eng - English
 Dates: 2016-03-232016-07
 Publication Status: Issued
 Pages: 19
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00018-016-2174-5
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Title: Cellular and Molecular Life Sciences
Source Genre: Journal
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Publ. Info: New York : Springer
Pages: - Volume / Issue: 73 (13) Sequence Number: - Start / End Page: 2491 - 2509 Identifier: -