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  Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology

Dunst, J., Azzouz, N., Liu, X., Tsukita, S., Seeberger, P. H., & Kamena, F. (2017). Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology. Frontiers in Cellular and Infection Microbiology, 7: 183. doi:10.3389/fcimb.2017.00183.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4794-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-590F-7
Genre: Journal Article

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 Creators:
Dunst, Josefine, Author
Azzouz, Nahid1, Author              
Liu, Xinyu, Author
Tsukita, Sachiko, Author
Seeberger, Peter H.2, Author              
Kamena, Faustin, Author
Affiliations:
1Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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 Abstract: Glycosylphosphatidylinositol (GPI) anchor of Plasmodium falciparum origin is considered an important toxin leading to severe malaria pathology through stimulation of pro-inflammatory responses from innate immune cells. Even though the GPI-induced immune response is widely described to be mediated by pattern recognition receptors such as TLR2 and TLR4, previous studies have revealed that these two receptors are dispensable for the development of severe malaria pathology. Therefore, this study aimed at the identification of potential alternative Plasmodium GPI receptors. Herein, we have identified the host protein moesin as an interaction partner of Plasmodium GPI in vitro. Given previous reports indicating the relevance of moesin especially in the LPS-mediated induction of pro-inflammatory responses, we have conducted a series of in vitro and in vivo experiments to address the physiological relevance of the moesin-Plasmodium GPI interaction in the context of malaria pathology. We report here that although moesin and Plasmodium GPI interact in vitro, moesin is not critically involved in processes leading to Plasmodium-induced pro-inflammatory immune responses or malaria-associated cerebral pathology.

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 Dates: 2017-05-162017
 Publication Status: Published in print
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 Identifiers: DOI: 10.3389/fcimb.2017.00183
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Title: Frontiers in Cellular and Infection Microbiology
Source Genre: Journal
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Pages: - Volume / Issue: 7 Sequence Number: 183 Start / End Page: - Identifier: ISBN: 2235-2988