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  Single Ca channel currents in mouse pancreatic B-cells.

Borsman, P., Ashcroft, F. M., & Trube, G. (1988). Single Ca channel currents in mouse pancreatic B-cells. Pflügers Archiv - European Journal of Physiology, 412(6), 597-603. doi:10.1007/BF00583760.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-463F-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4641-3
Genre: Journal Article

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 Creators:
Borsman, P., Author
Ashcroft, F. M., Author
Trube, G.1, Author              
Affiliations:
1Abteilung Zellphysiologie, MPI for biophysical chemistry, Max Planck Society, ou_578558              

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 Abstract: Barium currents flowing through single Ca2+ channels were recorded from outside-out patches isolated from mouse pancreatic B-cells. Only one type of Ca2+ channel was observed. In 110 mM Ba2+, the single channel conductance was 24 pS (at negative membrane potentials) and the current amplitude at 0 mV was−0.7 pA. Channel openings were activated by depolarisations more positive than −30 mV and showed little inactivation during 200 ms pulses. Open times were increased by BAY K 8644 an decreased by micromolar Cd2+. Channel activity was subject to rundown in excised patches and little activity remained after 10 min. These properties resemble those of L-type Ca2+ channels in other tissues. It is suggested that this Ca2+ channel participates in the generation of the B-cell action potential and mediates the increase in Ca2+ influx required for insulin secretion.

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Language(s): eng - English
 Dates: 1988-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/BF00583760
 Degree: -

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Title: Pflügers Archiv - European Journal of Physiology
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 412 (6) Sequence Number: - Start / End Page: 597 - 603 Identifier: -