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  Charged triazole cross-linkers for hyaluronan-based hybrid hydrogels

Martini, M., Hegger, P., Schädel, N., Baykal Minsky, B., Kirchhof, M., Scholl, S., et al. (2016). Charged triazole cross-linkers for hyaluronan-based hybrid hydrogels. Materials, 9(10): ma9100810, pp. 810-826. doi:10.3390/ma9100810.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-46FA-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-46FB-5
Genre: Journal Article

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Materials_9_2016_810.pdf (Any fulltext), 648KB
 
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 Creators:
Martini, Maike, Author
Hegger, Patricia1, Author              
Schädel, Nicole, Author
Baykal Minsky, Burcu1, Author              
Kirchhof, Manuel, Author
Scholl, Sebastian, Author
Southan, Alexander, Author
Tovar, Günter E.M., Author
Böhm, Heike1, Author              
Laschat, Sabine, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: hyaluronan; triazole; triazolium; hydrogels; cross-linking
 Abstract: Polyelectrolyte hydrogels play an important role in tissue engineering and can be produced from natural polymers, such as the glycosaminoglycan hyaluronan. In order to control charge density and mechanical properties of hyaluronan-based hydrogels, we developed cross-linkers with a neutral or positively charged triazole core with different lengths of spacer arms and two terminal maleimide groups. These cross-linkers react with thiolated hyaluronan in a fast, stoichiometric thio-Michael addition. Introducing a positive charge on the core of the cross-linker enabled us to compare hydrogels with the same interconnectivity, but a different charge density. Positively charged cross-linkers form stiffer hydrogels relatively independent of the size of the cross-linker, whereas neutral cross-linkers only form stable hydrogels at small spacer lengths. These novel cross-linkers provide a platform to tune the hydrogel network charge and thus the mechanical properties of the network. In addition, they might offer a wide range of applications especially in bioprinting for precise design of hydrogels.

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Language(s): eng - English
 Dates: 2016-07-282016-09-232016-09-30
 Publication Status: Published in print
 Pages: 27
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Materials
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 9 (10) Sequence Number: ma9100810 Start / End Page: 810 - 826 Identifier: Other: 1996-1944
CoNE: https://pure.mpg.de/cone/journals/resource/1996-1944