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  Evolutionary dynamics of selfish DNA explains the abundance distribution of genomic subsequences

Sheinman, M., Ramisch, A., Massip, F., & Arndt, P. F. (2016). Evolutionary dynamics of selfish DNA explains the abundance distribution of genomic subsequences. Scientific Reports, 6: 30851. doi:10.1038/srep30851.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-47A7-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-47A8-4
Genre: Journal Article

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Sheinman, M.1, Author              
Ramisch, A.2, Author              
Massip, F.1, Author              
Arndt, P. F.1, Author              
Affiliations:
1Evolutionary Genomics (Peter Arndt), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479638              
2Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              

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 Abstract: Since the sequencing of large genomes, many statistical features of their sequences have been found. One intriguing feature is that certain subsequences are much more abundant than others. In fact, abundances of subsequences of a given length are distributed with a scale-free power-law tail, resembling properties of human texts, such as Zipf’s law. Despite recent efforts, the understanding of this phenomenon is still lacking. Here we find that selfish DNA elements, such as those belonging to the Alu family of repeats, dominate the power-law tail. Interestingly, for the Alu elements the power-law exponent increases with the length of the considered subsequences. Motivated by these observations, we develop a model of selfish DNA expansion. The predictions of this model qualitatively and quantitatively agree with the empirical observations. This allows us to estimate parameters for the process of selfish DNA spreading in a genome during its evolution. The obtained results shed light on how evolution of selfish DNA elements shapes non-trivial statistical properties of genomes.

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Language(s): eng - English
 Dates: 2016-08-04
 Publication Status: Published online
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 Identifiers: DOI: 10.1038/srep30851
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 6 Sequence Number: 30851 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: /journals/resource/2045-2322