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  Fronto-temporal interactions are functionally relevant for semantic control in language processing

Wawrzyniak, M., Hoffstaedter, F., Klingbeil, J., Stockert, A., Wrede, K., Hartwigsen, G., et al. (2017). Fronto-temporal interactions are functionally relevant for semantic control in language processing. PLoS One, 12(5): e0177753. doi:10.1371/journal.pone.0177753.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4A73-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BD2F-5
Genre: Journal Article

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 Creators:
Wawrzyniak, Max1, Author              
Hoffstaedter, Felix2, 3, 4, Author
Klingbeil, Julian1, Author
Stockert, Anika1, Author
Wrede, Katrin1, Author
Hartwigsen, Gesa1, 5, Author              
Eickhoff, Simon B.2, 3, 4, Author
Classen, Joseph6, Author
Saur, Dorothee1, Author
Affiliations:
1Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
2Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
3Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
4Medical Faculty, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Human Cortical Physiology and Motor Control Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Abstract: Semantic cognition, i.e. processing of meaning is based on semantic representations and their controlled retrieval. Semantic control has been shown to be implemented in a network that consists of left inferior frontal (IFG), and anterior and posterior middle temporal gyri (a/pMTG). We aimed to disrupt semantic control processes with continuous theta burst stimulation (cTBS) over left IFG and pMTG and to study whether behavioral effects are moderated by induced alterations in resting-state functional connectivity. To this end, we applied real cTBS over left IFG and left pMTG as well as sham stimulation on 20 healthy participants in a within-subject design. Stimulation was followed by resting-state functional magnetic resonance imaging and a semantic priming paradigm. Resting-state functional connectivity of regions of interest in left IFG, pMTG and aMTG revealed highly interconnected left-lateralized fronto-temporal networks representing the semantic system. We did not find any significant direct modulation of either task performance or resting-state functional connectivity by effective cTBS. However, after sham cTBS, functional connectivity between IFG and pMTG correlated with task performance under high semantic control demands in the semantic priming paradigm. These findings provide evidence for the functional relevance of interactions between IFG and pMTG for semantic control processes. This interaction was functionally less relevant after cTBS over aIFG which might be interpretable in terms of an indirect disruptive effect of cTBS.

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Language(s): eng - English
 Dates: 2017-02-212017-05-022017-05-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0177753
PMID: 2850521
PMC: PMC5432178
Other: eCollection 2017
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Project name : Function, dysfunction and repair of language networks
Grant ID : 220020292
Funding program : Scholar Award Human Cognition
Funding organization : James S. McDonnell Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : University of Leipzig, Medical Faculty

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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 12 (5) Sequence Number: e0177753 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850