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  Regulation of calcium influx by second messengers in rat mast cells.

Penner, R., Matthews, G., & Neher, E. (1988). Regulation of calcium influx by second messengers in rat mast cells. Nature, 334(6182), 499-504. doi:10.1038/334499a0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4CC6-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-4CC9-0
Genre: Journal Article

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 Creators:
Penner, R.1, Author              
Matthews, G.1, Author              
Neher, E.1, Author              
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosis.

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Language(s): eng - English
 Dates: 1988-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/334499a0
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Title: Nature
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 334 (6182) Sequence Number: - Start / End Page: 499 - 504 Identifier: -