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  Rapid short-term reorganization in the language network

Hartwigsen, G., Bzdok, D., Klein, M., Wawrzyniak, M., Stockert, A., Wrede, K., et al. (2017). Rapid short-term reorganization in the language network. eLife, 6: e25964. doi:10.7554/eLife.25964.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-522F-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-BD2A-A
Genre: Journal Article

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 Creators:
Hartwigsen, Gesa1, Author              
Bzdok, Danilo2, Author
Klein, Maren3, Author
Wawrzyniak, Max2, Author              
Stockert, Anika2, Author
Wrede, Katrin2, Author
Classen, Joseph4, Author
Saur, Dorothee5, Author
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Germany, ou_persistent22              
3Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Human Cortical Physiology and Motor Control Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: aphasia; human; lesion; neuroscience; parietal cortex; semantic; stroke; transcranial magnetic stimulation
 Abstract: The adaptive potential of the language network to compensate for lesions remains elusive. We show that perturbation of a semantic region in the healthy brain induced suppression of activity in a large semantic network and upregulation of neighbouring phonological areas. After perturbation, the disrupted area increased its inhibitory influence on another semantic key node. The inhibitory influence predicted the individual delay in response speed, indicating that inhibition at remote nodes is functionally relevant. Individual disruption predicted the upregulation of semantic activity in phonological regions. In contrast, perturbation over a phonological region suppressed activity in the network and disrupted behaviour without inducing upregulation. The beneficial contribution of a neighbouring network might thus depend on the level of functional disruption and may be interpreted to reflect a differential compensatory potential of distinct language networks. These results might reveal generic mechanisms of plasticity in cognitive networks and inform models of language reorganization.

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Language(s): eng - English
 Dates: 2017-02-132017-05-232017-05-24
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.7554/eLife.25964
PMID: 28537558
PMC: PMC5472437
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Project name : -
Grant ID : HA-6314/1-1
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)
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Funding organization : James S. McDonnell Foundation

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Title: eLife
Source Genre: Journal
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Pages: - Volume / Issue: 6 Sequence Number: e25964 Start / End Page: - Identifier: Other: 2050-084X
CoNE: /journals/resource/2050-084X