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  Mechanical forces during muscle development

Lemke, S. B., & Schnorrer, F. (2017). Mechanical forces during muscle development. Mechanisms of Development, 144, 92-101. doi:10.1016/j.mod.2016.11.003.

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1-s2.0-S0925477316301046-main.pdf (Publisher version), 10MB
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© 2016 The Authors. Under a Creative Commons license
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 Creators:
Lemke, Sandra B.1, Author              
Schnorrer, Frank1, Author              
Affiliations:
1Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565168              

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Free keywords: NONMUSCLE MYOSIN-II; DROSOPHILA FLIGHT-MUSCLE; MYOBLAST FUSION; SKELETAL-MUSCLE; IN-VIVO; TISSUE MORPHOGENESIS; TENDON PROGENITORS; INTEGRIN TURNOVER; ELASTIC PROTEIN; CELL-ADHESIONDevelopmental Biology; Muscle; Tension; Force; Biomechanics; Sarcomere; Myofibrillogenesis; Self-organization; Integrin; Titin;
 Abstract: Muscles are the major force producing tissue in the human body. While certain muscle types specialize in producing maximum forces, others are very enduring. An extreme example is the heart, which continuously beats for the entire life. Despite being specialized, all body muscles share similar contractile mini-machines called sarcomeres that are organized into regular higher order structures called myofibrils. The major sarcomeric components and their organizational principles are conserved throughout most of the animal kingdom. In this review, we discuss recent progress in the understanding of myofibril and sarcomere development largely obtained from in vivo models. We focus on the role of mechanical forces during muscle and myofibril development and propose a tension driven self-organization mechanism for myofibril formation. We discuss recent technological advances that allow quantification of forces across tissues or molecules in vitro and in vivo. Although their application towards muscle development is still in its infancy, these technologies are likely to provide fundamental new insights into the mechanobiology of muscle and myofibril development in the near future. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

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Language(s): eng - English
 Dates: 2016-11-292017-04
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000398868100011
DOI: 10.1016/j.mod.2016.11.003
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Project name : -
Grant ID : 310939
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

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Title: Mechanisms of Development
Source Genre: Journal
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Publ. Info: Shannon : Elsevier
Pages: - Volume / Issue: 144 Sequence Number: - Start / End Page: 92 - 101 Identifier: ISSN: 0925-4773
CoNE: https://pure.mpg.de/cone/journals/resource/954927703126