Help Privacy Policy Disclaimer
  Advanced SearchBrowse


  Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients

Lois, G., Gerchen, M. F., Kirsch, P., Kanske, P., Schönfelder, S., & Wessa, M. (2017). Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients. Bipolar Disorders, 19(6), 487-495. doi:10.1111/bdi.12512.

Item is


show Files




Lois, Giannis1, Author
Gerchen, Martin F.2, Author
Kirsch, Peter2, Author
Kanske, Philipp3, Author              
Schönfelder, Sandra1, Author
Wessa, Michèle1, Author
1Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg University, Mainz, Germany, ou_persistent22              
2Central Institute of Mental Health, Mannheim, Germany, ou_persistent22              
3Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634552              


Free keywords: Bipolar disorder; Default mode network; Depression; Functional connectivity; Large-scale networks
 Abstract: Objectives The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. Methods We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of interest (default-mode, frontoparietal, salience, and dorsal attention networks). Using network contingency analysis and permutation testing, we estimated the likelihood that the number of significant condition-dependent connectivity changes in every pair of networks exceeds the number expected by chance. We first examined the pattern of functional connectivity in 42 healthy subjects (sample I) and then compared these connectivity patterns across healthy individuals (n=23) and remitted bipolar (n=21) and unipolar disorder patients (n=21) in an independent sample II. Results In sample I, distraction compared to reappraisal was characterized by reduced connectivity within the default-mode network and between the default-mode and two cognitive control networks and increased connectivity among the cognitive control networks. In sample II, both patient groups exhibited abnormally increased default-mode intra- and inter-network connectivity during distraction compared to reappraisal. Conclusions The present study highlights the role of large-scale network interactions in emotion regulation and provides preliminary evidence of default-mode inter- and intra-network connectivity impairments in remitted bipolar and unipolar patients during emotion regulation.


Language(s): eng - English
 Dates: 2017-03-082017-05-312017-09-272017-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/bdi.12512
PMID: 28960669
Other: Epub 2017
 Degree: -



Legal Case


Project information

show hide
Project name : -
Grant ID : WE 3638/3‐1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01GQ1003B
Funding program : -
Funding organization : German Ministry of Education and Research (BMBF)

Source 1

Title: Bipolar Disorders
Source Genre: Journal
Publ. Info: Oxford : Wiley-Blackwell
Pages: - Volume / Issue: 19 (6) Sequence Number: - Start / End Page: 487 - 495 Identifier: ISSN: 1398-5647
CoNE: https://pure.mpg.de/cone/journals/resource/1398-5647