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  Real time band selective F-1-decoupled proton NMR for the demixing of overlay spectra of chiral molecules.

Nath, N., Verma, A., Baishya, B., & Khetrapal, C. L. (2017). Real time band selective F-1-decoupled proton NMR for the demixing of overlay spectra of chiral molecules. Magnetic Resonance in Chemistry, 55(6), 553-558. doi:10.1002/mrc.4547.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-593B-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3BA6-2
Genre: Journal Article

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 Creators:
Nath, N.1, Author              
Verma, A., Author
Baishya , B., Author
Khetrapal, C. L., Author
Affiliations:
1Department of NMR Based Structural Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_578567              

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Free keywords: Chiral discrimination; Pure shift NMR; Chiral liquid crystal; Lanthanide shift reagent
 Abstract: The small chemical shift dispersion and complex multiplicity pattern in proton NMR limit quantifications, for instance the determination of enantiomeric excess (ee) for an enantiomeric mixture. Herein, we present a simple proton-proton correlation experiment with band selective homonuclear (BASH) decoupling in both F-1 and F-2 dimensions, for the removal of scalar and residual dipolar couplings to provide collapsed singlet for each chemical site. The method has been demonstrated to separate the severely overlapped spectra of enantiomers using both chiral isotropic and anisotropic phases as well as a small biomolecule, particularly for the diastereotopic protons and also for the determination of ee.

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Language(s): eng - English
 Dates: 2016-11-032017-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrc.4547
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Title: Magnetic Resonance in Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 55 (6) Sequence Number: - Start / End Page: 553 - 558 Identifier: -