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  Towards MRI temperature mapping in real time-the proton resonance frequency method with undersampled radial MRI and nonlinear inverse reconstruction.

Zhang, Z., Michaelis, T., & Frahm, J. (2017). Towards MRI temperature mapping in real time-the proton resonance frequency method with undersampled radial MRI and nonlinear inverse reconstruction. Quantitative Imaging in Medicine and Surgery, 7(2), 251-258. doi:10.21037/qims.2017.03.03.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-5A6F-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-57E2-E
Genre: Journal Article

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 Creators:
Zhang, Z.1, Author              
Michaelis, T.1, Author              
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Hyperthermia; temperature mapping; thermometry; radial MRI; real-time MRI
 Abstract: Background: Optimal control of minimally invasive interventions by hyperthermia requires dynamic temperature mapping at high temporal resolution. Methods: Based on the temperature-dependent shift of the proton resonance frequency (PRF), this work developed a method for real-time MRI thermometry which relies on highly undersampled radial FLASH MRI sequences with iterative image reconstruction by regularized nonlinear inversion (NLINV). As a first step, the method was validated with use of a temperature phantom and ex vivo organs (swine kidney) subjected to heating by warm water or a pulsed laser source. Results: The temperature maps obtained by real-time PRF MRI demonstrate good accuracy as independently controlled by fiber-optic temperature sensors. Moreover, the dynamic results demonstrate both excellent sensitivity to single laser pulses (20 ms duration, 6 J energy output) and high temporal resolution, i.e., 200 ms acquisition times per temperature map corresponding to a rate of 5 frames per second. In addition, future extensions to in vivo applications were prepared by addressing the breathingrelated motion problem by a pre-recorded library of reference images representative of all respiratory states. Conclusions: The proposed method for real-time MRI thermometry now warrants further developments towards in vivo MRI monitoring of thermal interventions in animals.

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Language(s): eng - English
 Dates: 2017-042017-04
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.21037/qims.2017.03.03
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Title: Quantitative Imaging in Medicine and Surgery
Source Genre: Journal
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Pages: - Volume / Issue: 7 (2) Sequence Number: - Start / End Page: 251 - 258 Identifier: -