English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.

Turriani, E., Lázaro, D. F., Ryazanov, S., Leonov, A., Giese, A., Schön, M., et al. (2017). Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death. Proceedings of the National Academy of Sciences of the United States of America, 114(25), E4971-E4977. doi:10.1073/pnas.1700200114.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-5CED-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-5255-3
Genre: Journal Article

Files

show Files
hide Files
:
2451256.pdf (Publisher version), 2MB
Name:
2451256.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
2451256_Suppl.DCSupplemental (Supplementary material), 42KB
Name:
2451256_Suppl.DCSupplemental
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/xhtml+xml / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Turriani, E.1, Author              
Lázaro, D. F., Author
Ryazanov, S.2, Author              
Leonov, A.2, Author              
Giese, A., Author
Schön, M., Author
Schön, M. P., Author
Griesinger, C.2, Author              
Outeiro, T. F.2, Author              
Arndt-Jovin, D. J.1, Author              
Becker, D.2, Author              
Affiliations:
1Emeritus Group Laboratory of Cellular Dynamics, MPI for Biophysical Chemistry, Max Planck Society, ou_578629              
2Department of NMR-based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

Content

show
hide
Free keywords: melanoma; Parkinson's disease; α-synuclein; oligomer modulator treatment; autophagy
 Abstract: Recent epidemiological and clinical studies have reported a significantly increased risk for melanoma in people with Parkinson’s disease. Because no evidence could be obtained that genetic factors are the reason for the association between these two diseases, we hypothesized that of the three major Parkinson’s disease-related proteins—α-synuclein, LRRK2, and Parkin—α-synuclein might be a major link. Our data, presented here, demonstrate that α-synuclein promotes the survival of primary and metastatic melanoma cells, which is the exact opposite of the effect that α-synuclein has on dopaminergic neurons, where its accumulation causes neuronal dysfunction and death. Because this detrimental effect of α-synuclein on neurons can be rescued by the small molecule anle138b, we explored its effect on melanoma cells. We found that treatment with anle138b leads to massive melanoma cell death due to a major dysregulation of autophagy, suggesting that α-synuclein is highly beneficial to advanced melanoma because it ensures that autophagy is maintained at a homeostatic level that promotes and ensures the cell’s survival.

Details

show
hide
Language(s): eng - English
 Dates: 2017-06-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1700200114
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 114 (25) Sequence Number: - Start / End Page: E4971 - E4977 Identifier: -