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  Enzymatic site-selectivity enabled by structure-guided directed evolution

Wang, J., Li, G., & Reetz, M. T. (2017). Enzymatic site-selectivity enabled by structure-guided directed evolution. Chemical Communications, 53(28), 3916-3928. doi:10.1039/c7cc00368d.

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 Creators:
Wang, Jianbo1, 2, Author              
Li, Guangyue1, 2, Author              
Reetz, Manfred T.1, 2, Author              
Affiliations:
1Department of Chemistry, Philipps-University Marburg, Hans-Meerwein Strasse 4, Marburg, Germany , ou_persistent22              
2Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              

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 Abstract: Biocatalytic site-selective (regioselective) organic transformations have been practiced for decades, but the traditional limitations of enzymes regarding narrow substrate acceptance and the often observed insufficient degree of selectivity have persisted until recently. With the advent of directed evolution, it is possible to engineer site-selectivity to suit the needs of organic chemists. This review features recent progress in this exciting research area, selected examples involving P450 monooxygenases, halogenases and Baeyer–Villiger monooxygenases being featured for illustrative purposes. The complementary nature of enzymes and man-made catalysts is emphasized.

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Language(s): eng - English
 Dates: 2017-04-11
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/c7cc00368d
 Degree: -

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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 53 (28) Sequence Number: - Start / End Page: 3916 - 3928 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413