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  One-thousand-fold enhancement of high field liquid nuclear magnetic resonance signals at room temperature.

Liu, G., Levien, M., Karschin, N., Parigi, G., Luchinat, C., & Bennati, M. (2017). One-thousand-fold enhancement of high field liquid nuclear magnetic resonance signals at room temperature. Nature Chemistry, 9(7), 676-680. doi:10.1038/nchem.2723.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-7719-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2FAF-7
Genre: Journal Article

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 Creators:
Liu, G.1, Author              
Levien, M., Author
Karschin, N., Author
Parigi, G., Author
Luchinat, C., Author
Bennati, M.1, Author              
Affiliations:
1Research Group of Electron Paramagnetic Resonance, MPI for Biophysical Chemistry, Max Planck Society, ou_578606              

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 Abstract: Nuclear magnetic resonance (NMR) is a fundamental spectroscopic technique for the study of biological systems and materials, molecular imaging and the analysis of small molecules. It detects interactions at very low energies and is thus non-invasive and applicable to a variety of targets, including animals and humans. However, one of its most severe limitations is its low sensitivity, which stems from the small interaction energies involved. Here, we report that dynamic nuclear polarization in liquid solution and at room temperature can enhance the NMR signal of 13C nuclei by up to three orders of magnitude at magnetic fields of ∼3 T. The experiment can be repeated within seconds for signal averaging, without interfering with the sample magnetic homogeneity. The method is therefore compatible with the conditions required for high-resolution NMR. Enhancement of 13C signals on various organic compounds opens up new perspectives for dynamic nuclear polarization as a general tool to increase the sensitivity of liquid NMR.

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Language(s): eng - English
 Dates: 2017-02-132017-07
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nchem.2723
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Title: Nature Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 9 (7) Sequence Number: - Start / End Page: 676 - 680 Identifier: -