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  Side-chain effects on the structures of protonated amino acid dimers: A gas-phase infrared spectroscopy study

Seo, J., Hoffmann, W., Malerz, S., Warnke, S., Bowers, M. T., Pagel, K., et al. (2018). Side-chain effects on the structures of protonated amino acid dimers: A gas-phase infrared spectroscopy study. International Journal of Mass Spectrometry, 429, 115-120. doi:10.1016/j.ijms.2017.06.011.

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2017
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 Creators:
Seo, Jongcheol1, Author              
Hoffmann, Waldemar1, 2, Author              
Malerz, Sebastian1, 2, Author
Warnke, Stephan1, Author              
Bowers, Michael T.3, Author
Pagel, Kevin2, Author
Helden, Gert von1, Author              
Affiliations:
1Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
2Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany, ou_persistent22              
3Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, USA, ou_persistent22              

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 Abstract: A protonated amino acid can interact in several ways with another uncharged amino acid molecule to form a protonated dimer. In case of amino acids that do not have basic or acidic side chains, the most likely protonation site is the amino group and the then protonated amine can be involved in a pairwise interaction with a neutral amine, a carboxylic acid, a carboxylate group and/or the sidechain of the partner amino acid. Here, we employ gas-phase infrared spectroscopy and density functional theory to identify these pairwise interactions in protonated homodimers of serine, isoleucine, phenylalanine and tyrosine. The results show the influence of the different side-chains on the respective interactions. A charge-solvated structure with pairwise interaction between a protonated amine and a neutral amine is preferred if the side chain can provide additional stabilizing interaction with the positive charge. In contrast, for amino acids where the side chain only interacts weakly with the protonated amine group, a protonated dimer is formed by an interaction between the protonated amine and the neutral carboxylic acid of the second amino acid.

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Language(s): eng - English
 Dates: 2017-02-072017-06-222017-07-012018-06
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.ijms.2017.06.011
 Degree: -

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Title: International Journal of Mass Spectrometry
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 429 Sequence Number: - Start / End Page: 115 - 120 Identifier: ISSN: 1387-3806
CoNE: https://pure.mpg.de/cone/journals/resource/954926232412