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  Plasticity of mitochondrial translation.

Dennerlein, S., Wang, C., & Rehling, P. (2017). Plasticity of mitochondrial translation. Trends in Cell Biology, 27(10), 712-721. doi:10.1016/j.tcb.2017.05.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-7FC8-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-FF24-8
Genre: Journal Article

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2457142.pdf (Publisher version), 2MB
 
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 Creators:
Dennerlein, S., Author
Wang, C., Author
Rehling, P.1, Author              
Affiliations:
1Max Planck Fellow Peter Rehling, ou_1298545              

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Free keywords: OXPHOS assembly; mitochondria; mitochondrial ribosome; respiratory chain; translation regulation
 Abstract: Mitochondria maintained a genome during evolution to synthesize core subunits of the oxidative phosphorylation system. Expression of the mitochondrial genome requires intraorganellar replication, transcription, and translation. Membrane-associated ribosomes translate mitochondrial-encoded proteins and facilitate co-translational insertion of newly synthesized polypeptides into the inner membrane. Considering that mitochondrial-encoded proteins assemble with imported, nuclear-encoded proteins into enzyme complexes of the oxidative phosphorylation system, it is expected that expression of mitochondrial genes should adapt to the availability of their nuclear-encoded partners. Recent work shows that mitochondrial translation is influenced by the cellular environment. We discuss how mitochondrial translation is affected by the cellular environment and propose models of translational plasticity that modulate mitochondrial translation in response to the availability of imported proteins.

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Language(s): eng - English
 Dates: 2017-06-092017-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.tcb.2017.05.004
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Title: Trends in Cell Biology
Source Genre: Journal
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Pages: - Volume / Issue: 27 (10) Sequence Number: - Start / End Page: 712 - 721 Identifier: -