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  Selfing in haploid plants and efficacy of selection: codon usage bias in the model moss Physcomitrella patens

Szövényi, P., Ullrich, K. K., Rensing, S. A., Lang, D., van Gessel, N., Stenøien, H. K., et al. (2017). Selfing in haploid plants and efficacy of selection: codon usage bias in the model moss Physcomitrella patens. Genome Biology and Evolution, 9(1), 1528-1546. doi:10.1093/gbe/evx098.

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 Urheber:
Szövényi, Péter, Autor
Ullrich, Kristian K.1, Autor           
Rensing, Stefan A, Autor
Lang, Daniel, Autor
van Gessel, Nico, Autor
Stenøien, Hans K, Autor
Conti, Elena, Autor
Reski, Ralf, Autor
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Schlagwörter: codon usage; moss; effective population size; inbreeding; natural selection; genetic drift
 Zusammenfassung: Long term reduction in effective population size will lead to major shift in genome evolution. In particular, when effective population size is small, genetic drift becomes dominant over natural selection. The onset of self-fertilization is one evolutionary event considerably reducing effective size of populations. Theory predicts that this reduction should be more dramatic in organisms capable for haploid than for diploid selfing. Although theoretically well-grounded, this assertion received mixed experimental support. Here we test this hypothesis by analyzing synonymous codon usage bias of genes in the model moss Physcomitrella patens frequently undergoing haploid selfing. In line with population genetic theory, we found that the effect of natural selection on synonymous codon usage bias is very weak. Our conclusion is supported by four independent lines of evidence: a) Very weak or nonsignificant correlation between gene expression and codon usage bias; b) No increased codon usage bias in more broadly expressed genes; c) No evidence that codon usage bias would constrain synonymous and nonsynonymous divergence; d) Predominant role of genetic drift on synonymous codon usage predicted by a model-based analysis. These findings show striking similarity to those observed in AT-rich genomes with weak selection for optimal codon usage and GC content overall. Our finding is in contrast to a previous study reporting adaptive codon usage bias in the moss P. patens.

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Sprache(n): eng - English
 Datum: 2016-12-012017-05-252017-05-26
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: DOI: 10.1093/gbe/evx098
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Titel: Genome Biology and Evolution
  Andere : GBE
  Kurztitel : Genome Biol Evol
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford : Oxford Univ. Press
Seiten: - Band / Heft: 9 (1) Artikelnummer: - Start- / Endseite: 1528 - 1546 Identifikator: Anderer: 1759-6653
CoNE: https://pure.mpg.de/cone/journals/resource/1759-6653