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  Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

Greiner, A. M., Sales, A., Chen, H., Biela, S., Kaufmann, D., & Kemkemer, R. (2016). Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein Journal of Nanotechnology, 7, 1620-1641. doi:10.3762/bjnano.7.155.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-93AB-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-93AC-1
Genre: Journal Article

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BeilsteinJ Nanotechnol_7_2016_1620.pdf (Any fulltext), 6MB
 
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 Creators:
Greiner, Alexandra M., Author
Sales, Adriá, Author
Chen, Hao, Author
Biela, Sarah, Author
Kaufmann, Dieter, Author
Kemkemer, Ralf1, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: fabrication methods; materials selection; nano- and micro-topography; vascular endothelial cells; vascular smooth muscle cells
 Abstract: The extracellular environment of vascular cells in vivo is complex in its chemical composition, physical properties, and architecture. Consequently, it has been a great challenge to study vascular cell responses in vitro, either to understand their interaction with their native environment or to investigate their interaction with artificial structures such as implant surfaces. New procedures and techniques from materials science to fabricate bio-scaffolds and surfaces have enabled novel studies of vascular cell responses under well-defined, controllable culture conditions. These advancements are paving the way for a deeper understanding of vascular cell biology and materials–cell interaction. Here, we review previous work focusing on the interaction of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) with materials having micro- and nanostructured surfaces. We summarize fabrication techniques for surface topographies, materials, geometries, biochemical functionalization, and mechanical properties of such materials. Furthermore, various studies on vascular cell behavior and their biological responses to micro- and nanostructured surfaces are reviewed. Emphasis is given to studies of cell morphology and motility, cell proliferation, the cytoskeleton and cell-matrix adhesions, and signal transduction pathways of vascular cells. We finalize with a short outlook on potential interesting future studies.

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Language(s): eng - English
 Dates: 2016-03-262016-10-042016-11-082016-11-08
 Publication Status: Published in print
 Pages: 22
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3762/bjnano.7.155
 Degree: -

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Title: Beilstein Journal of Nanotechnology
Source Genre: Journal
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Publ. Info: Frankfurt am Main : Beilstein-Institut
Pages: - Volume / Issue: 7 Sequence Number: - Start / End Page: 1620 - 1641 Identifier: ISSN: 2190-4286
CoNE: https://pure.mpg.de/cone/journals/resource/2190-4286