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  Chemical kinetics of multiphase reactions between ozone and human skin lipids: Implications for indoor air quality and health effects

Lakey, P. S. J., Wisthaler, A., Berkemeier, T., Mikoviny, T., Pöschl, U., & Shiraiwa, M. (2017). Chemical kinetics of multiphase reactions between ozone and human skin lipids: Implications for indoor air quality and health effects. Indoor air: international journal of indoor air quality and climate, 27(4), 816-828. doi:10.1111/ina.12360.

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 Creators:
Lakey, Pascale S. J.1, Author              
Wisthaler, A.2, Author
Berkemeier, T.1, Author              
Mikoviny, T.2, Author
Pöschl, U.1, Author              
Shiraiwa, M.1, Author              
Affiliations:
1Multiphase Chemistry, Max Planck Institute for Chemistry, Max Planck Society, ou_1826290              
2external, ou_persistent22              

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 Abstract: Ozone reacts with skin lipids such as squalene, generating an array of organic compounds, some of which can act as respiratory or skin irritants. Thus, it is important to quantify and predict the formation of these products under different conditions in indoor environments. We developed the kinetic multilayer model that explicitly resolves mass transport and chemical reactions at the skin and in the gas phase (KM-SUB-Skin). It can reproduce the concentrations of ozone and organic compounds in previous measurements and new experiments. This enabled the spatial and temporal concentration profiles in the skin oil and underlying skin layers to be resolved. Upon exposure to ~30 ppb ozone, the concentrations of squalene ozonolysis products in the gas phase and in the skin reach up to several ppb and on the order of ~10 mmol m−3. Depending on various factors including the number of people, room size, and air exchange rates, concentrations of ozone can decrease substantially due to reactions with skin lipids. Ozone and dicarbonyls quickly react away in the upper layers of the skin, preventing them from penetrating deeply into the skin and hence reaching the blood.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000403895400011
DOI: 10.1111/ina.12360
 Degree: -

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Title: Indoor air : international journal of indoor air quality and climate
Source Genre: Journal
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Publ. Info: Oxford : Wiley-Blackwell
Pages: - Volume / Issue: 27 (4) Sequence Number: - Start / End Page: 816 - 828 Identifier: Other: 1600-0668
CoNE: https://pure.mpg.de/cone/journals/resource/1600-0668