English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants

Reinmuth-Selzle, K., Kampf, C. J., Lucas, K., Lang-Yona, N., Fröhlich-Nowoisky, J., Shiraiwa, M., et al. (2017). Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environmental Science & Technology, 51(8), 4119-4141. doi:10.1021/acs.est.6b04908.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Reinmuth-Selzle, K.1, Author              
Kampf, C. J.1, Author              
Lucas, K.1, Author              
Lang-Yona, N.1, Author              
Fröhlich-Nowoisky, J.1, Author              
Shiraiwa, M.1, Author              
Lakey, Pascale S. J.1, Author              
Lai, S.1, Author              
Liu, Fobang1, Author              
Kunert, A. T.1, Author              
Ziegler, K.1, Author              
Shen, F.1, Author              
Sgarbanti, Rossella2, Author
Weber, B.1, Author              
Bellinghausen, Iris2, Author
Saloga, Joachim2, Author
Weller, Michael G.2, Author
Duschl, Albert2, Author
Schuppan, Detlef2, Author
Pöschl, U.1, Author              
Affiliations:
1Multiphase Chemistry, Max Planck Institute for Chemistry, Max Planck Society, ou_1826290              
2external, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Air pollution and climate change are potential drivers for the increasing burden of allergic diseases. The molecular mechanisms by which air pollutants and climate parameters may influence allergic diseases, however, are complex and elusive. This article provides an overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies. We reviewed and synthesized key findings from atmospheric, climate, and biomedical research. The current state of knowledge, open questions, and future research perspectives are outlined and discussed. The Anthropocene, as the present era of globally pervasive anthropogenic influence on planet Earth and, thus, on the human environment, is characterized by a strong increase of carbon dioxide, ozone, nitrogen oxides, and combustion- or traffic-related particulate matter in the atmosphere. These environmental factors can enhance the abundance and induce chemical modifications of allergens, increase oxidative stress in the human body, and skew the immune system toward allergic reactions. In particular, air pollutants can act as adjuvants and alter the immunogenicity of allergenic proteins, while climate change affects the atmospheric abundance and human exposure to bioaerosols and aeroallergens. To fully understand and effectively mitigate the adverse effects of air pollution and climate change on allergic diseases, several challenges remain to be resolved. Among these are the identification and quantification of immunochemical reaction pathways involving allergens and adjuvants under relevant environmental and physiological conditions.

Details

show
hide
Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000399859700002
DOI: 10.1021/acs.est.6b04908
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Environmental Science & Technology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Easton, PA : American Chemical Society
Pages: - Volume / Issue: 51 (8) Sequence Number: - Start / End Page: 4119 - 4141 Identifier: ISSN: 0013-936X
CoNE: https://pure.mpg.de/cone/journals/resource/954921342157