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  Breaking TADs: How Alterations of Chromatin Domains Result in Disease

Lupiáñez, D. G., Spielmann, M., & Mundlos, S. (2016). Breaking TADs: How Alterations of Chromatin Domains Result in Disease. Trends in Genetics, 32(4), 225-237. doi:10.1016/j.tig.2016.01.003.

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Lupiáñez.pdf (Publisher version), 3MB
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© 2016 Elsevier Ltd
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Lupiáñez, D. G., Author
Spielmann, M.1, Author           
Mundlos, S.1, Author           
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1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

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Free keywords: Chromatin/*chemistry/genetics *Genetic Predisposition to Disease Humans CRISPR/Cas Tad disease long-range regulation structural variations topologically associating domains
 Abstract: Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is thought to guide regulatory elements to their cognate promoters. In this review we summarize the most recent findings about TADs and the boundary regions separating them. We discuss how the disruption of these structures by genomic rearrangements can result in gene misexpression and disease.

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Language(s): eng - English
 Dates: 2016-02-072016-04
 Publication Status: Issued
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tig.2016.01.003
ISSN: 0168-9525
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Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
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Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 32 (4) Sequence Number: - Start / End Page: 225 - 237 Identifier: ISSN: 0168-9525
CoNE: https://pure.mpg.de/cone/journals/resource/954925485719