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Free keywords:
Chromatin/*chemistry/genetics
*Genetic Predisposition to Disease
Humans
CRISPR/Cas
Tad
disease
long-range regulation
structural variations
topologically associating domains
Abstract:
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is thought to guide regulatory elements to their cognate promoters. In this review we summarize the most recent findings about TADs and the boundary regions separating them. We discuss how the disruption of these structures by genomic rearrangements can result in gene misexpression and disease.