English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Breaking TADs: How Alterations of Chromatin Domains Result in Disease

Lupiáñez, D. G., Spielmann, M., & Mundlos, S. (2016). Breaking TADs: How Alterations of Chromatin Domains Result in Disease. Trends in Genetics, 32(4), 225-237. doi:10.1016/j.tig.2016.01.003.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1D1D-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-1D1E-B
Genre: Journal Article

Files

show Files
hide Files
:
Lupiáñez.pdf (Publisher version), 3MB
Name:
Lupiáñez.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2016 Elsevier Ltd
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Lupiáñez, D. G., Author
Spielmann, M.1, Author              
Mundlos, S.1, Author              
Affiliations:
1Research Group Development & Disease (Head: Stefan Mundlos), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433557              

Content

show
hide
Free keywords: Chromatin/*chemistry/genetics *Genetic Predisposition to Disease Humans CRISPR/Cas Tad disease long-range regulation structural variations topologically associating domains
 Abstract: Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is thought to guide regulatory elements to their cognate promoters. In this review we summarize the most recent findings about TADs and the boundary regions separating them. We discuss how the disruption of these structures by genomic rearrangements can result in gene misexpression and disease.

Details

show
hide
Language(s): eng - English
 Dates: 2016-02-072016-04
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.tig.2016.01.003
ISSN: 0168-9525
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Trends in Genetics
  Other : Trends Genet.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier Current Trends
Pages: - Volume / Issue: 32 (4) Sequence Number: - Start / End Page: 225 - 237 Identifier: ISSN: 0168-9525
CoNE: /journals/resource/954925485719