English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Olfactory bulbectomy in mice triggers transient and long-lasting behavioral impairments and biochemical hippocampal disturbances.

de Almeida, R. F., Ganzella, M., Machado, D. G., Loureiro, S. O., Leffa, D., Quincozes-Santos, A., et al. (2017). Olfactory bulbectomy in mice triggers transient and long-lasting behavioral impairments and biochemical hippocampal disturbances. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 76, 1-11. doi:10.1016/j.pnpbp.2017.02.013.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-9E19-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1D4F-8
Genre: Journal Article

Files

show Files
hide Files
:
2463764.pdf (Publisher version), 2MB
Name:
2463764.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
de Almeida, R. F., Author
Ganzella, M.1, Author              
Machado, D. G., Author
Loureiro, S. O., Author
Leffa, D., Author
Quincozes-Santos, A., Author
Pettenuzzo, L. F., Author
Duarte, M. M. M. F., Author
Duarte, T., Author
Souza, D. O., Author
Affiliations:
1Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society, ou_578595              

Content

show
hide
Free keywords: Major depressive disorder; Olfactory bulbectomy; Open field test; Mitochondrial; Synaptosome preparation
 Abstract: Major depressive disorder (MDD) is a neuropsychiatric disease that is associated with profound disturbances in affected individuals. Elucidating the pathophysiology of MDD has been frustratingly slow, especially concerning the neurochemical events and brain regions associated with disease progression. Thus, we evaluated the time course (up to 8 weeks) behavioral and biochemical effects in mice that underwent to a bilateral olfactory bulbectomy (OBX), which is used to modeling depressive-like behavior in rodents. Similar to the symptoms in patients with MDD, OBX induced long-lasting (e.g., impairment of habituation to novelty, hyperactivity and an anxiety-like phenotype) and transient (e.g., loss of self-care and motivational behavior) behavioral effects. Moreover, OBX temporarily impaired hippocampal synaptosomal mitochondria, in a manner that would be associated with hippocampal-related synaptotoxicity. Finally, long-lasting pro-oxidative (i.e., increased levels of reactive oxygen species and nitric oxide and decreased glutathione levels) and pro-inflammatory (i.e., increased levels of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and decreased anti-inflammatory cytokine IL-10 levels) effects were induced in the hippocampus by OBX. Additionally, these parameters were transiently affected in the posterior and frontal cortices. This study is the first to suggest that the transient and long-lasting behavioral effects from OBX strongly correlate with mitochondrial, oxidative and inflammatory parameters in the hippocampus; furthermore, these effects show a weak correlation with these parameters in the cortex. Our findings highlight the underlying mechanisms involved in the biochemical time course of events related to depressive behavior. (C) 2017 Elsevier Inc. All rights reserved.

Details

show
hide
Language(s): eng - English
 Dates: 2017-02-202017-06-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.pnpbp.2017.02.013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 76 Sequence Number: - Start / End Page: 1 - 11 Identifier: -