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  Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance

Keck, T., Hübener, M., & Bonhoeffer, T. (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Current Opinion in Neurobiology, 43, 87-93. doi:10.1016/j.conb.2017.02.003.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-A609-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-A60A-9
Genre: Journal Article

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 Creators:
Keck, Tara1, Author
Hübener, Mark2, Author              
Bonhoeffer, Tobias2, Author              
Affiliations:
1external, ou_persistent22              
2Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: MOUSE VISUAL-CORTEX; OCULAR DOMINANCE PLASTICITY; FIRING RATE HOMEOSTASIS; LONG-TERM POTENTIATION; AXON INITIAL SEGMENT; IN-VIVO; MONOCULAR DEPRIVATION; DENDRITIC SPINES; AMPA RECEPTOR; DEPENDENT PLASTICITYNeurosciences & Neurology;
 Abstract: Homeostatic plasticity is proposed to be mediated by synaptic changes, such as synaptic scaling and shifts in the excitation/inhibition balance. These mechanisms are thought to be separate from the Bienenstock, Cooper, Munro (BCM) learning rule, where the threshold for the induction of long-term potentiation and long-term depression slides in response to changes in activity levels. Yet, both sets of mechanisms produce a homeostatic response of a relative increase (or decrease) in strength of excitatory synapses in response to overall activity-level changes. Here we review recent studies, with a focus on in vivo experiments, to re-examine the overlap and differences between these two mechanisms and we suggest how they may interact to facilitate firing-rate homeostasis, while maintaining functional properties of neurons.

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Language(s): eng - English
 Dates: 2017
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: Current Opinion in Neurobiology
  Other : Curr. Opin.Neurobiol.
Source Genre: Journal
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Publ. Info: New York, NY : Elsevier Current Trends
Pages: - Volume / Issue: 43 Sequence Number: - Start / End Page: 87 - 93 Identifier: ISSN: 0959-4388
CoNE: /journals/resource/954925578066