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  Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila

Li, J., Terry, E. E., Fejer, E., Gamba, D., Hartmann, N., Logsdon, J., et al. (2017). Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila. Brain, Behavior, and Immunity, 61, 127-136. doi:10.1016/j.bbi.2016.11.012.

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 Creators:
Li, Jiajia, Author
Terry, Erin E., Author
Fejer, Edith, Author
Gamba, Diana, Author
Hartmann, Natalie, Author
Logsdon, Joseph, Author
Michalski, Daniel, Author
Rois, Lisa E., Author
Scuderi, Maria J., Author
Kunst, Michael1, Author           
Hughes, Michael E., Author
Affiliations:
1Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Free keywords: REV-ERB-ALPHA; INNATE IMMUNITY; INFLAMMATORY CYTOKINES; RHEUMATOID-ARTHRITIS; EXPRESSION; SYSTEM; SLEEP; RHYTHMS; MACROPHAGES; PROTEINSImmunology; Neurosciences & Neurology; Circadian clock; Immunity; Achilles; CG17386; Drosophila; Antimicrobial peptides; Gene expression; Genomics; RNA-seq; Bacterial infection; Fat body; RNA-binding protein;
 Abstract: The circadian clock is a transcriptional/translational feedback loop that drives the rhythmic expression of downstream mRNAs. Termed "clock-controlled genes,"these molecular outputs of the circadian clock orchestrate cellular, metabolic, and behavioral rhythms. As part of our on-going work to characterize key upstream regulators of circadian mRNA expression, we have identified a novel clock-controlled gene in Drosophila melanogaster, Achilles (Achl), which is rhythmic at the mRNA level in the brain and which represses expression of antimicrobial peptides in the immune system. Achilles knock-down in neurons dramatically elevates expression of crucial immune response genes, including IM1 (Immune induced molecule 1), Mtk (Metchnikowin), and Drs (Drosomysin). As a result, flies with knocked-down Achilles expression are resistant to bacterial challenges. Meanwhile, no significant change in core clock gene expression and locomotor activity is observed, suggesting that Achilles influences rhythmic mRNA outputs rather than directly regulating the core timekeeping mechanism. Notably, Achilles knock-down in the absence of immune challenge significantly diminishes the fly's overall lifespan, indicating a behavioral or metabolic cost of constitutively activating this pathway. Together, our data demonstrate that (1) Achilles is a novel clock-controlled gene that (2) regulates the immune system, and (3) participates in signaling from neurons to immunological tissues. (C) 2016 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2017-03-01
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000395365900015
DOI: 10.1016/j.bbi.2016.11.012
 Degree: -

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Title: Brain, Behavior, and Immunity
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 61 Sequence Number: - Start / End Page: 127 - 136 Identifier: ISSN: 0889-1591
CoNE: https://pure.mpg.de/cone/journals/resource/954922649133