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  Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride

Verhoog, S., Pfeifer, L., Khotavivattana, T., Calderwood, S., Collier, T. L., Wheelhouse, K., et al. (2016). Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride. Synlett, 27(1), 25-28. doi:10.1055/s-0035-1560592.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-B100-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-B101-2
Genre: Journal Article

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 Creators:
Verhoog, Stefan1, Author
Pfeifer, Lukas1, Author
Khotavivattana, Tanatorn1, Author
Calderwood, Samuel1, Author
Collier, Thomas Lee2, Author
Wheelhouse, Katherine3, Author
Tredwell, Mathew1, 4, Author           
Gouverneur, Véronique1, Author
Affiliations:
1University of Oxford, Chemistry Research laboratory, 12 Mansfield Road, OX1 3TA, Oxford, UK , ou_persistent22              
2Advion BioSystems, 10 Brown Road, Suite 101, Ithaca, NY 14850, USA, ou_persistent22              
3Medicines Discovery & Development, GlaxoSmithKline, R&D, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK, ou_persistent22              
4Research Group Tredwell, Max-Planck-Institut für Kohlenforschung, Max Planck Society, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, DE, ou_2466692              

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Free keywords: radiochemistry - halogen exchange - silver - fluoride - trifluoromethylarenes - difluoromethylarenes
 Abstract: We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

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Language(s): eng - English
 Dates: 2015-10-162015-11-032015-11-202016-01-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1055/s-0035-1560592
 Degree: -

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Title: Synlett
  Other : Synlett
Source Genre: Journal
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Publ. Info: Stuttgart : Georg Thieme Verlag
Pages: - Volume / Issue: 27 (1) Sequence Number: - Start / End Page: 25 - 28 Identifier: ISSN: 0936-5214
CoNE: https://pure.mpg.de/cone/journals/resource/954925570856