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  GABA signaling stimulates α-cell-mediated β-like cell neogenesis.

Napolitano, T., Avolio, F., Vieira, A., Ben-Othmann, N., Courtney, M., Gjernes, E., et al. (2017). GABA signaling stimulates α-cell-mediated β-like cell neogenesis. Communicative and Integrative Biology, 10(3): e1300215. doi:10.1080/19420889.2017.1300215.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-B168-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-3BA5-3
Genre: Journal Article

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 Creators:
Napolitano, T., Author
Avolio, F., Author
Vieira, A., Author
Ben-Othmann, N., Author
Courtney, M., Author
Gjernes, E., Author
Hadzic, B., Author
Druelle, N., Author
Navarro Sanz, S., Author
Silvano, S., Author
Mansouri, A.1, Author              
Collombat, P., Author
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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Free keywords: Arx; GABA; Pax4; diabetes; β-cell regeneration
 Abstract: Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.

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Language(s): eng - English
 Dates: 2017-03-02
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1080/19420889.2017.1300215
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Title: Communicative and Integrative Biology
Source Genre: Journal
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Pages: 3 Volume / Issue: 10 (3) Sequence Number: e1300215 Start / End Page: - Identifier: -